Biofabrication

Leistungsangebot Biofabrication

Fertigungsverfahren für Tissue-Engineering

  • Photopolymerisation von natürlichen und künstlichen Polymeren zur Generierung von Freiform-Scaffolds (Auflösung: 5 µm - < 1 µm)
  • Strukturieren und Perforieren von Polymermaterial zur Zellbesiedelung. Herstellung von angepassten Strukturen durch Abtrag, Bohren oder auch lokale Umschmelzung
  • Schweißen und Fügen von Polymermaterial zur Zellbesiedelung.

in vitro-Testsysteme und Microarrays

  • Lokales Auftragen niedrig- bis hochviskoser Flüssigkeiten (Polymere, Organische Elektronik, Biomoleküle wie Proteine) und Feststoffe
  • Berührungsfreie Handhabung von Minimalmengen und Positionierung von Zellen
  • Kundenorientierte, maßgeschneiderte 3D-Mikrostrukturen zur Untersuchung von biomechanischen und zellbiologischen Eigenschaften

Publikationen

Buyel, J. F., Gruchow, H. M., Tödter, N., Wehner, M.:
Determination of the thermal properties of leaves by non-invasive contact-free laser probing
J. Biotechnol. 217, 100-108 (2016)

Jauer, L., Leonards, H.:
3D-Druck und Biofabrikation
RWTH-Themen (1), 42-45 (2014)

Riester, D., Özmert, A., Wehner, M.:
Laser tool for single cell transfer
J. Laser Micro/Nanoeng. 9, (2) 93-97 (2014)

Engelghardt, S., Refle, O., Wehner, M.:
Method for the fabrication of macroscopic high resolution scaffolds by the combination of inkjet-printing and laser initiated polymerization
J. Tissue Engl. Regen. Med. 6 299-200 (2012)

Meyer, W., Engelhardt, S., Novosel, E., Elling, B., Wegener, M., Krüger, H.:
Soft polymers for building up small and smallest blood supplying systems by stereolithography
J. Funct. Biomater. 3, 257-268 (2012)

Riester, DA,, Özmert, A., Ungers, M., Wehner, M.:
What you see is what you print: Single cell transfer
J. Tissue Engl. Regen. Med. 6, 374-374 (2012)

Engelhardt, S., Hu, Y., Seiler, N., Riester, D., Meyer, W., Krüger, H., Wehner, M., Bremus-Köbberling, E., Gillner, A.:
3D-microfabrication of polymer-protein hybrid structures with a q-switched microlaser
J. Laser Micro/Nanoeng. 6, Nr.1, 54-58, (2011)

Engelhardt, S., Hoch, E., Borchers, K., Meyer, W., Krüger, H., Tovar, G. E. M., Gillner, A.:
Fabrication of 2D protein microstructures and 3D polymer-protein hybrid microstructures by two-photon polymerization
Biofabrication 3, 025003, 9 S., (2011)

Genov, S., Riester, D., Hirth, T., Tovar, G., Borchers, K., Weber, A.:
Preparation and characterisation of dry thin native protein trehalose films on titanium-coated cycloolefin polymer (COP) foil generated by spin-coating/drying process and applied for protein transfer by Lase-Induced-Forward-Transfer (LIFT)
Chem. Eng. Process. 50, Nr. 5-6, 556-564, (2011)

Genov, S., Thurow, I., Riester, D., Hirth, T., Borchers, K., Weber, A., Tovar, G. E. M.:
Dry native protein assays on substrates by non-contact laser-induced-forward transfer LIFT process
Nanotech 2010, Anaheim/Ca., June 21-24, 4 S., (2010)

Genov, S., Riester, D., Hirth, T., Tovar, G., Borchers, K., Weber, A.:
Preparation and characterisation of dry thin native protein trehalose films on titanium-coated cyclo-olefin polymer (COP) foil generated by spin-coating/drying process and applied for protein transfer by Laser-Induced-Forward-Transfer (LIFT)
Chem. Eng. Proc. Process Intensification, in Pr., doi: 10.1016/j.cep.2010.11.001, (2010)

Wehner, M., Jacobs, P., Esser, D., Schinkel, H., Schillberg, S.:
Laser-mediated perforation of plant cells
Proc. SPIE
6632, 9 S., (2007)