Products and Services Biofunctionalization


  • Micro und nanoscale surface tailoring
  • Cell guidance structures
  • Spatially selective  immobilization of proteins and growth factors
  • Contactless handling of very small volumes for coating purposes
  • Photo chemical and photo thermal surface modification
  • Altering wetting properties
  • Linker for the covalent immobilization of biofunctional molecules and markers
  • Gradients of  signaling molecules
  • Laser-induced drug release


Nottrodt, N., Leonhäuser, D., Elling, L., Bremus-Köbberling, E., Gillner, A.:
Laser based functionalization for graded immobilization of biomolecules on biocompatible polymer surfaces
In: Nanobio Europe, Münster, Germany, June 2-4, 2014,
10th Int. Congr. & Exhibition on Nanobiotechnology (1 S.)  (2014)

Bremus-Koebberling, E., Beckemper, S.,  Koch, B.,  Gillner, A.
Nano structures via laser interference patterning for guided cell growth of neuronal cells
Journal of Laser Applications, Special Issue „ Generation of  Sub-100 nm Structures by Nonlinear Laser-Material Interaction”

Bremus-Köbberling, E., Leonards, H., Naderi, M.:
Spatially selective modification of polymeric scaffolds with markers for MR-Imaging
J. Tissue Engl. Regen. Med. 6, 316-316 (2012)

Bremus-Köbberling, E., Gillner, A., Avemaria, F., Réthoré, C., Bräse, S.:
Photochemistry with laser radiation in condensed phase using miniaturized photoreactors
Beilstein J. Org. Chem. 8, 1213-1218, (2012)

Leonards, H., Schmitz, D., Pich, A., Bremus-Köbberling, E.:
Light triggered drug release
J. Tissue Engl. Regen. Med. 6, 324-324 (2012)

Engelhardt, S., Hu, Y., Seiler, N., Riester, D., Meyer, W., Krüger, H., Wehner, M., Bremus-Köbberling, E., Gillner, A.:
3D-microfabrication of polymer-protein hybrid structures with a q-switched microlaser. 
J. Laser Micro/Nanoeng. 6, Nr.1, 54-58, (2011)

Seiler, N., Engelhardt, S., Riester, D., Mela, P., Bremus-Köbberling, E.
Laserinduzierte Gradienten zur Oberflächenfunktionlaisierung von Polymeren
Biomed. Tech. 55, Suppl. 1, 34-36, (2010)