Bioanalytics

Our Service

Compact laser systems are in great demand in chemistry and biotechnology, for example for particle or process analysis. Used here are, for example, the laser light scattering analysis and the laser induced fluorescence. Besides being used to examine fluorescence intensity, fluorescence lifetime and fluorescence polarization can also be applied for analytical purposes. With the laser, particle sizes can be precisely determined or specific biomolecules can be stimulated and identified via the subsequently emitted light. The focus of research and development is, for example, the design of corresponding inline measuring systems as well as the implementation and further development of waveguide technology, probes for chemical process analysis and compact lock-in amplifiers. For measuring devices in the field of food analysis or applications in flow measurement technology, the laser-based methods developed at Fraunhofer ILT are just as suitable as for applications in biotechnology.

The range of services covers all areas of the development chain of application-specific analysis systems. For example, the Fraunhofer ILT offers its customers feasibility studies on individual tasks, the further development of processes, the integration of analysis systems into existing processes, and advice on the design of plants.

Standard series for ELISA determination
© Fraunhofer ILT, Aachen, Germany.

Standard series for ELISA determination

Near field microscope.
© Fraunhofer ILT, Aachen, Germany.

Near field microscope.

Live cell imaging of tissue cultures.
© Fraunhofer ILT, Aachen, Germany.

Live cell imaging of tissue cultures.

Bioanalytics

  • Confocal measurement techniques, chemical analysis in microplates
  • Raman spectroscopy for bio-molecules, difference Raman spectroscopy, confocal Raman spectroscopy
  • Static and dynamic laser light scattering in small sample volumes (µl - nl), analysis of aggregations and interaction potentials
  • Fluorescence based methods: Fluorescence lifetime, fluorescence polarization
  • Immunochemical analytics (detection techniques based on antibodies)
  • Tunable laser from near infrared to vacuum UV

Brochures

Our brochures offer a quick view onto the service portfolio “Bioanalytics“. Find more detailed information in the “project results“ tab.

 

Brochure “Biofunctionalization with Laser Radiation“

Publications

Janzen, C., Hoffmann, K.:
Optical measurements for the rational screening of protein crystallization conditions
In: Handbook of Biophotonics Vol. 3: Photonics in Pharmaceutics, Bioanalysis and Environmental Research
Jürgen Popp (Editor), Valery V. Tuchin (Editor), Arthur Chiou (Editor), Stefan H. Heinemann (Editor)
Weinheim: WILEY-VCH, 257-287 (2012)

257-287 (2012)Jahnke, J., Mahlmann, D. M.
Differences in the cellular dry weight per unit biovolume of Phormidium autumnale (Cyanobacteria) dependent on growth conditions
J. Appl. Phycol. 22, 117-122
2010

Jahnke, J., Mahlmann, D., Jacobs, P., Priefer, U.
The influence of growth conditions on the cellular dry weight per unit biovolume of Klebsormidium flaccidum (Charophyta), a typical ubiquitous soil alga
J. Appl. Phycol. DOI 10.1007/s10811-010-9557-z
2010

Spiess, A.C., Zavrel, M., Ansorge-Schumacher, M.B., Janzen, C., Michalik, C., Schmidt, T.W., Schwendt, T., Büchs, J., Poprawe, R., Marquardt, W.
Model discrimination for the propionic acid diffusion into hydrogel beads using lifetime confocal laser scanning microscopy
Chemical Engineering Science 63, Nr.13, S.3457-3465
2008